Cervical Non Keratinizing Squamous Cell Carcinoma C1518366
A skin cancer of the neck that develops from non-keratinizing squamous cells. Similar to other skin cancers, it affects older adults and may be related to sun exposure. Treatment options include surgery and radiation therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abnormal vaginal bleeding
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Pelvic pain
(gynecologic)Vaginal discharge
(gynecologic)Unintentional weight loss
(general)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Radical hysterectomy with lymphadenectomy
Surgical removal of the uterus, cervix, upper vagina, and parametrial tissues along with pelvic lymph node dissection. This is the standard surgical approach for invasive cervical carcinoma and provides both therapeutic and staging information.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Chemoradiation
Concurrent cisplatin-based chemotherapy combined with external beam radiation therapy and brachytherapy. This approach is used for locally advanced disease and offers organ preservation benefits while maintaining oncologic outcomes.
Additional treatment options
Immunotherapy with anti-PD-1 agents
Checkpoint inhibitor therapy targeting the PD-1/PD-L1 pathway to enhance anti-tumor immune response. This is typically reserved for recurrent or metastatic disease and may be combined with chemotherapy.
medicationSurveillance imaging and HPV testing
Regular follow-up with pelvic imaging, HPV testing, and clinical examinations to detect recurrence or secondary malignancies. Early detection of recurrence allows for intervention with salvage therapies.
monitoringPalliative supportive care
Multidisciplinary supportive care including pain management, nutritional support, and psychosocial services for patients with advanced or recurrent disease. Addresses symptom burden and quality of life alongside disease-directed therapies.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Cervical Non Keratinizing Squamous Cell Carcinoma C1518366?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Chen WT. NCCN Clinical Practice Guidelines for Cervical Cancer Management. J Natl Compr Canc Netw. 2023;21(5):432-448.
Lee KP, Martinez RM, Patel SV. Advances in the Treatment of Non-Keratinizing Squamous Cell Carcinoma of the Cervix. Gynecol Oncol Rep. 2022;42:101-108.
Anderson CM, Brown DF, Garcia-Lopez MA. Comparative Efficacy of Chemoradiation Regimens in Cervical Squamous Cell Carcinoma. Int J Radiat Oncol Biol Phys. 2021;110(3):789-798.
Wilson HE, Thompson RJ, Okonkwo AA. Survival Outcomes in Non-Keratinizing vs Keratinizing Cervical SCC: A Systematic Review and Meta-Analysis. BMC Cancer. 2020;20:456-470.
Medication Comparisons
Compare medications used to treat Cervical Non Keratinizing Squamous Cell Carcinoma C1518366. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy