Charcot Marie Tooth Disease Axonal Autosomal Recessive Type 2a2b C4310725
An autosomal recessive inherited neuropathy affecting nerve fibers, leading to progressive muscle weakness and sensory loss. Management focuses on physical therapy and supportive care.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness (lower limbs)
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Pes cavus (high-arched feet)
(neurologic)Hand weakness (distal upper limb)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Intensive Physical Rehabilitation Program
Comprehensive physical therapy focusing on gait training, proprioception exercises, and progressive resistance training to maintain strength and functional mobility in autosomal recessive CMT2a2b.
Adaptive Footwear and Gait Aids
Custom orthopedic footwear, ankle supports, and appropriate gait aids such as walkers or canes to maximize safety and mobility in axonal CMT2a2b.
Additional treatment options
Corrective Foot and Ankle Surgery
Surgical reconstruction of severe foot deformities including tendon transfers, osteotomies, and joint stabilization procedures in patients with CMT2a2b who fail conservative management.
surgicalPsychological Support and Counseling
Provision of mental health support to address the chronic nature of CMT2a2b, including coping strategies for disability, anxiety, and depression that may accompany progressive neuropathy.
psychologicalMultidisciplinary Disease Monitoring
Regular follow-up with neurology, orthopedics, physiatry, and physical therapy to comprehensively track disease progression and optimize interventions in CMT2a2b.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Autosomal Recessive Type 2a2b C4310725?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C, Salsano E. Diagnosis and management of Charcot-Marie-Tooth disease subtypes. Neurology. 2021.
Bird TD. Charcot-Marie-Tooth Hereditary Neuropathy Overview. GeneReviews. 2020.
Cartwright MS, Brown ME, Dundar K, et al. Efficacy of rehabilitation in Charcot-Marie-Tooth disease: a randomized controlled trial. J Peripher Nerv Syst. 2019.
Rossor AM, Polke JM, Houlden H, Reilly MM. Clinical implications of genetic advances in Charcot-Marie-Tooth disease. Nat Rev Neurol. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy