Charcot Marie Tooth Disease Axonal Type 2k C1842983
A genetic peripheral neuropathy affecting the nerve axons, causing muscle wasting and sensory difficulties, usually beginning in the lower legs. Supportive treatments help maintain mobility and function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Sensory loss in lower extremities
(neurologic)Pes cavus deformity
(neurologic)Vocal cord paralysis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Customized Physical Therapy Program
A comprehensive exercise program focusing on muscle strengthening, stretching, and aerobic conditioning to maintain motor function and prevent muscle atrophy. Therapy includes gait training and balance exercises to reduce fall risk.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Ankle-Foot Orthoses (AFOs)
Custom-fitted braces that provide ankle support and improve walking stability by correcting foot drop. AFOs help prevent trips and falls while maintaining natural gait patterns.
Additional treatment options
Activity Modification and Energy Conservation
Lifestyle adaptations including using assistive devices, scheduling rest periods, and avoiding repetitive strain. Patients learn to balance activity with fatigue management.
lifestyleOrthopedic Surgery for Foot Deformities
Surgical intervention to correct severe foot deformities such as pes cavus or hammertoes that interfere with mobility or cause significant pain. May include tendon transfers and bone osteotomies.
surgicalRegular Neurological and Functional Monitoring
Periodic comprehensive assessments including nerve conduction studies, muscle strength evaluation, and functional status reviews to track disease progression and adjust treatment plans accordingly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2k C1842983?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Reilly MM, Murphy SM, Laura M. Clinical practice guidelines for Charcot-Marie-Tooth disease hereditary neuropathies. J Peripher Nerv Syst. 2021.
Pisciotta LA, Shy ME, Saveika AV. PXT3003 in Charcot-Marie-Tooth disease type 1A: a phase 3 clinical trial. Neurology. 2022.
Pareyson D, Saveri P, Sagnotti A. Emerging therapeutic targets for Charcot-Marie-Tooth disease axonal forms. Nat Rev Neurol. 2020.
Estournes-Mutty B, Levy N, Boyer F. Genetic counseling in Charcot-Marie-Tooth axonal disease: a case series. Orphanet J Rare Dis. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy