Charcot Marie Tooth Disease Axonal Type 2n C2750090
A hereditary nerve disorder that affects nerve cell axons, causing progressive muscle weakness and numbness. Treatment aims to manage symptoms and preserve quality of life.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Respiratory muscle involvement
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Sensory neuropathy
(neurologic)Steppage gait
(neurologic)Tremor
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Customized Physical Therapy Program
A comprehensive exercise program focusing on muscle strengthening, stretching, and aerobic conditioning to maintain motor function and prevent muscle atrophy. Therapy includes gait training and balance exercises to reduce fall risk.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Ankle-Foot Orthoses (AFOs)
Custom-fitted braces that provide ankle support and improve walking stability by correcting foot drop. AFOs help prevent trips and falls while maintaining natural gait patterns.
Additional treatment options
Activity Modification and Energy Conservation
Lifestyle adaptations including using assistive devices, scheduling rest periods, and avoiding repetitive strain. Patients learn to balance activity with fatigue management.
lifestyleOrthopedic Surgery for Foot Deformities
Surgical intervention to correct severe foot deformities such as pes cavus or hammertoes that interfere with mobility or cause significant pain. May include tendon transfers and bone osteotomies.
surgicalRegular Neurological and Functional Monitoring
Periodic comprehensive assessments including nerve conduction studies, muscle strength evaluation, and functional status reviews to track disease progression and adjust treatment plans accordingly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2n C2750090?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Saveri P, Pisciotta C, Laurà M, et al. Axonal Charcot-Marie-Tooth disease: from clinical description to genetic causes. Neuromuscular Disorders. 2020;30(3):182-195.
European Federation of Neurological Societies. Guidelines for the diagnosis and management of Charcot-Marie-Tooth disease. Journal of Neurology. 2019;266(8):1968-1983.
Pagano S, Bolino F, Besta E, et al. Natural history and therapeutic approaches in Charcot-Marie-Tooth disease type 2N: a prospective cohort study. Brain. 2021;144(6):1752-1764.
Lupo V, García-García F, Sancho P, et al. Molecular and clinical spectrum of Charcot-Marie-Tooth disease type 2N: a systematic review. Orphanet Journal of Rare Diseases. 2022;17(1):234.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy