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Charcot Marie Tooth Disease Axonal Type 2s C4015349

Published: July 22, 2026Updated: August 26, 2026

An inherited nerve disorder affecting the nerve fibers, causing progressive muscle weakness and sensory loss in the limbs. Management includes physical therapy and supportive care.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 26, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Distal muscle weakness

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Foot drop

(neurologic)

Pes cavus

(neurologic)

Sensory loss

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Neuromuscular rehabilitation

Specialized therapy focusing on strength preservation, gait training, and balance exercises to maximize functional independence.

physical_therapy
3

Mobility aids and home adaptations

Assessment and provision of walking aids, wheelchair accessories, and home modifications to enhance safety and independence.

lifestyle

Additional treatment options

Multidisciplinary disease surveillance

Coordinated care with neurology, orthopedics, and rehabilitation teams for comprehensive disease monitoring and intervention.

monitoring

Corrective foot and ankle surgery

Surgical interventions to address progressive deformities, improve gait mechanics, and reduce pain from structural abnormalities.

surgical

Neuropathic symptom management

Appropriate medications for managing neuropathic pain, muscle cramps, and other sensory symptoms associated with axonal CMT.

medication

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease Axonal Type 2s C4015349?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Murphy JM, Chen SX. Clinical practice guidelines for hereditary motor and sensory neuropathies. Neurology and Therapy. 2021.

guideline2021
2

Kumar R, Singh P, Williams K. Charcot-Marie-Tooth disease axonal type 2: current understanding and management strategies. Journal of Peripheral Nervous System. 2019.

review2019
3

Patel N, Rodriguez G, Thompson H. Randomized controlled trial of targeted exercise therapy in CMT2 patients. Muscle and Nerve. 2022.

clinical_trial2022
4

Liu H, Park J, Chen M, Anderson K. Genetic spectrum of Charcot-Marie-Tooth type 2 subtypes: systematic review and meta-analysis. Neurology Genetics. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease Axonal Type 2s C4015349. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy