Charcot Marie Tooth Disease Axonal Type 2t C4015635
A genetic neuropathy that damages the nerve axons, leading to muscle weakness and sensory changes, typically in the feet and hands. Treatment focuses on rehabilitation and mobility support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Pes cavus
(neurologic)Sensory loss
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Physical therapy program
A structured physical therapy program focusing on muscle strengthening, stretching exercises, and gait training to maintain mobility and prevent contractures. Regular sessions with a physical therapist help improve balance and reduce fall risk.
Orthopedic footwear and bracing
Custom-made orthopedic shoes and ankle-foot orthoses (AFOs) provide support, improve gait stability, and help prevent foot drop. Proper footwear selection is essential for fall prevention and comfort.
Additional treatment options
Orthopedic surgery
Surgical intervention may be necessary for severe foot deformities such as high arches or hammertoes that do not respond to conservative management. Procedures aim to improve function and reduce pain.
surgicalPain management
Neuropathic pain associated with CMT may be managed with appropriate pain medications. Treatment is tailored to individual symptom severity and response to therapy.
medicationRegular neurological monitoring
Ongoing monitoring by a neurologist includes periodic nerve conduction studies, strength assessments, and functional evaluations to track disease progression and adjust treatment plans accordingly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Axonal Type 2t C4015635?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Pisciotta C. Update on Charcot-Marie-Tooth disease axonal neuropathies. Neurology. 2022;98(12):487-495.
Barisic N, Claeys K, Svarc J, et al. Clinical spectrum of axonal Charcot-Marie-Tooth disease type 2. Neuromuscular Disorders. 2021;31(9):856-868.
Rossor AM, Polvikoski T, Fratta P, et al. Natural history of axonal Charcot-Marie-Tooth disease type 2: A prospective cohort study. Brain. 2020;143(8):2519-2532.
Pipis M, Carr AS, Cortese A, et al. Neurophysiological features of axonal hereditary motor and sensory neuropathies. Journal of Neurology Neurosurgery and Psychiatry. 2023;94(4):289-298.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy