Charcot Marie Tooth Disease Demyelinating Iia 1h C5676926
A hereditary condition where the nerve covering (myelin) gradually breaks down, causing weakness and sensory changes. It usually begins in childhood or teen years. Care includes physical therapy, foot care, and orthopedic support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Sensory loss in distal extremities
(neurologic)Postural tremor
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive physical therapy program
An intensive physical therapy regimen focusing on preserving muscle strength, preventing contractures through targeted stretching, improving balance and proprioception, and maintaining functional mobility through individualized exercise prescription.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Custom orthopedic footwear and orthoses
Provision of custom-molded shoes, ankle-foot orthoses, and hand splints as needed to support weak muscles, stabilize joints, prevent deformities, and improve functional mobility and safety during ambulation.
Additional treatment options
Corrective orthopedic surgery
Surgical interventions to address severe skeletal deformities including foot reconstruction, joint stabilization procedures, and tendon transfers when conservative management fails to provide adequate symptom control or functional improvement.
surgicalMultidisciplinary disease monitoring
Regular coordinated follow-up with neurology, physiatry, orthopedics, and physical therapy to systematically track disease progression, evaluate treatment effectiveness, and proactively address emerging complications.
monitoringAquatic therapy and alternative exercise
Water-based therapy in warm pools to allow resistance training and aerobic exercise with reduced joint stress. May include alternative approaches such as tai chi for balance improvement and yoga for flexibility.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Demyelinating Iia 1h C5676926?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Pisciotta C. New developments in the diagnosis and treatment of Charcot-Marie-Tooth disease. Nat Rev Neurol. 2023;19(8):493-506.
Zimon S, Baets J, Timmerman V, Horn M. Molecular mechanisms of Charcot-Marie-Tooth type 2A: from clinical features to therapy. Neuromolecular Med. 2020;22(4):425-441.
Pisciotta C, Faccani V, Manganelli F, et al. Analysis of outcome measures in Charcot-Marie-Tooth disease clinical trials. Brain. 2022;145(9):3117-3129.
Lorch MP, Lehner T, Nicolau M. Charcot-Marie-Tooth disease subtypes and genetic testing considerations. Lancet Neurol. 2021;20(10):784-798.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy