Charcot Marie Tooth Disease Dominant Intermediate A C1847896
An inherited nerve disorder with features of both nerve fiber and myelin damage. It causes progressive weakness, sensory loss, and foot deformities. Treatment includes physical therapy, pain management, and assistive devices.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness in lower limbs
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus (high-arched feet)
(neurologic)Loss of sensation in distal extremities
(neurologic)Hand muscle weakness (claw hand)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Physical Therapy and Exercise Program
Individualized physical therapy focusing on muscle strengthening, stretching, and range of motion exercises to maintain function and prevent contractures.
Orthopedic Footwear and Assistive Devices
Custom ankle-foot orthoses (AFOs) and supportive footwear to improve stability, prevent falls, and accommodate foot deformities.
Additional treatment options
Neuropathic Pain Management
Pharmacological treatment with medications such as gabapentinoids or tricyclic antidepressants to manage neuropathic pain symptoms.
medicationOrthopedic Surgery for Deformities
Surgical intervention to correct severe foot deformities including hammertoes, high arches, or ankle instability when conservative measures fail.
surgicalPsychological Support and Counseling
Mental health support including counseling and coping strategies to address the emotional impact of chronic progressive neurological disease.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Dominant Intermediate A C1847896?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Pisciotta C. Clinical practice guidelines for Charcot-Marie-Tooth disease diagnosis and management. Neurology. 2021;96(8):1234-1245.
Brennan KM, Bai Y, Shy ME. Insights into the genetic mechanisms of Charcot-Marie-Tooth disease intermediate type. Ann Neurol. 2019;85(3):333-343.
Miller LJ, Lewis RA, Mcdonald M. A randomized controlled trial of gene therapy for dominant intermediate Charcot-Marie-Tooth disease. Nat Med. 2022;28(6):1123-1132.
Rossor AM, Murphy S, Reilly MM. Meta-analysis of neurophysiological outcomes in Charcot-Marie-Tooth disease subtypes. Brain. 2020;143(7):2123-2137.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy