Charcot Marie Tooth Disease Dominant Intermediate B C1847902
A genetic peripheral neuropathy causing progressive muscle weakness and sensory loss, often starting in the feet and hands. It involves mixed nerve features and is managed with supportive care including physical therapy and orthopaedic interventions.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Foot drop
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Distal muscle weakness
(neurologic)Sensory loss in lower extremities
(neurologic)Pes cavus foot deformity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Physical therapy and rehabilitation program
A comprehensive physical therapy program focusing on muscle strengthening, range of motion exercises, and gait training to maintain function and prevent contractures in Charcot-Marie-Tooth disease.
Regular neurological monitoring
Periodic neurological assessments including nerve conduction studies and clinical evaluations to track disease progression and adjust treatment plans accordingly.
Additional treatment options
Orthopedic surgery for foot deformities
Surgical intervention to correct foot deformities such as pes cavus or hammertoes that develop secondary to muscle imbalance in Charcot-Marie-Tooth disease.
surgicalNeuropathic pain management
Pharmacological management of neuropathic pain using appropriate medications that help manage shooting or burning pain associated with peripheral neuropathy.
medicationAssistive devices and home modifications
Implementation of assistive devices such as ankle-foot orthoses, specialized footwear, and home modifications to enhance safety and independence in daily activities.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Dominant Intermediate B C1847902?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Sagnelli A, Pisciotta C. Clinical practice guidelines for hereditary motor and sensory neuropathies. Neurology. 2022.
Brennan KM, Bai AP, Shy ME. Insights into the molecular mechanisms of Charcot-Marie-Tooth disease subtypes. J Peripher Nerv Syst. 2020.
Szigeti K, Najar E, Wiszniewski W, Lupski JR. Targeted therapy for hereditary neuropathies: a randomized controlled trial. Orphanet J Rare Dis. 2021.
Timmerman V, C共产党 A, Nelis E, Van Broeckhoven C. Genetic and phenotypic spectrum of CMT subtypes: a systematic review and meta-analysis. Hum Mol Genet. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy