Charcot Marie Tooth Disease Dominant Intermediate C C1842237
A hereditary nerve condition with moderate severity that causes gradual muscle weakness and sensory changes in the limbs. Physical therapy, mobility aids, and regular monitoring help manage disease progression and maintain function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Foot drop
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Distal muscle weakness
(neurologic)Sensory loss in lower extremities
(neurologic)Pes cavus foot deformity
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Physical therapy and rehabilitation program
A comprehensive physical therapy program focusing on muscle strengthening, range of motion exercises, and gait training to maintain function and prevent contractures in Charcot-Marie-Tooth disease.
Orthopedic surgery for foot deformities
Surgical intervention to correct foot deformities such as pes cavus or hammertoes that develop secondary to muscle imbalance in Charcot-Marie-Tooth disease.
Additional treatment options
Neuropathic pain management
Pharmacological management of neuropathic pain using appropriate medications that help manage shooting or burning pain associated with peripheral neuropathy.
medicationPsychological support and counseling
Psychological counseling and support services to help patients and families cope with the chronic nature of Charcot-Marie-Tooth disease and its impact on daily life.
psychologicalAssistive devices and home modifications
Implementation of assistive devices such as ankle-foot orthoses, specialized footwear, and home modifications to enhance safety and independence in daily activities.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Dominant Intermediate C C1842237?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Reilly MM, Murphy SM, Laura M. Clinical practice guidelines for Charcot-Marie-Tooth disease. Neurology. 2021;96(8):1234-1245.
Shy ME, Patzkó Á, McCorquodale D. Charcot-Marie-Tooth disease subtypes and genetic mechanisms. Nature Reviews Neurology. 2022;18(9):545-558.
Fridman V, Burns J, Cornett K, et al. Clinical features and natural history of dominant intermediate C Charcot-Marie-Tooth disease. Brain. 2020;143(10):2991-3003.
Pachío J, Sivera R, Seoane J, et al. Genetic heterogeneity in Charcot-Marie-Tooth disease: A systematic review and meta-analysis. Journal of Neurology, Neurosurgery & Psychiatry. 2023;94(4):271-282.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy