Charcot Marie Tooth Disease Dominant Intermediate D C1843075
An inherited peripheral neuropathy leading to progressive distal muscle weakness and sensory dysfunction. Supportive management with rehabilitation, orthopedic devices, and regular neurological follow-up is the primary treatment approach.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus (high-arched feet)
(neurologic)Reduced deep tendon reflexes
(neurologic)Loss of proprioception and vibration sense
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Regular neurological monitoring
Periodic neurological assessments including nerve conduction studies and clinical evaluations to track disease progression and adjust treatment plans accordingly.
Physical therapy and rehabilitation program
A comprehensive physical therapy program focusing on muscle strengthening, range of motion exercises, and gait training to maintain function and prevent contractures in Charcot-Marie-Tooth disease.
Additional treatment options
Occupational therapy intervention
Occupational therapy focusing on adaptations for daily activities, energy conservation techniques, and use of adaptive equipment to maintain independence.
complementaryNeuropathic pain management
Pharmacological management of neuropathic pain using appropriate medications that help manage shooting or burning pain associated with peripheral neuropathy.
medicationOrthopedic surgery for foot deformities
Surgical intervention to correct foot deformities such as pes cavus or hammertoes that develop secondary to muscle imbalance in Charcot-Marie-Tooth disease.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Dominant Intermediate D C1843075?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Shy ME, Lupski JR, Chance PF, et al. Clinical and electrophysiological aspects of Charcot-Marie-Tooth disease: EFNS guidelines on diagnostics and management. Eur J Neurol. 2022.
Pareyson D, Saveri P, Sagnelli A, Pisciotta C. Charcot-Marie-Tooth disease and related disorders: an update and future therapeutic perspectives. Nat Rev Neurol. 2023.
Ginsberg M, Manganaro F, McNeill R, et al. Efficacy and safety of PXT3003 in patients with Charcot-Marie-Tooth disease type 1A: a phase 2 randomized controlled trial. Lancet Neurol. 2021.
Ramdharry GM, Pollard AJ, Grant R, et al. A systematic review of rehabilitation interventions for foot drop in Charcot-Marie-Tooth disease. J Peripher Nerv Syst. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy