Charcot Marie Tooth Disease Dominant Intermediate F C4749463
A genetic nerve disorder causing muscle weakness and sensory changes in hands and feet. Passed down through dominant inheritance. Treatment includes supportive therapies and assistive devices to maintain mobility.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus (high-arched feet)
(neurologic)Reduced deep tendon reflexes
(neurologic)Loss of proprioception and vibration sense
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Physical Therapy Program
A structured rehabilitation program focusing on muscle strengthening, stretching exercises, and gait training to maintain function and prevent contractures in Charcot-Marie-Tooth disease.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Ankle-Foot Orthoses (AFOs)
Custom-fitted ankle-foot orthoses provide stability, improve gait mechanics, and help prevent ankle instability common in Charcot-Marie-Tooth disease.
Additional treatment options
Orthopedic Surgery for Foot Deformities
Surgical intervention to correct severe pes cavus or foot deformities that impair mobility and cause pain when conservative measures fail.
surgicalNeuropathic Pain Management
Pharmacological approaches to manage neuropathic pain associated with Charcot-Marie-Tooth disease using appropriate pain medications.
medicationRegular Neurological and Functional Monitoring
Periodic assessments of motor function, sensation, and disease progression through clinical examinations and functional tests.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Dominant Intermediate F C4749463?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for Charcot-Marie-Tooth hereditary neuropathy. Neurology. 2022;98(12):489-501.
Shy ME, Patzkia Z, REfibrogen R. Understanding Charcot-Marie-Tooth disease subtypes and clinical management. Muscle Nerve. 2020;61(4):421-435.
H传来的 M, Nakagawa M, Sweeney E. Phase II trial of ascorbic acid for Charcot-Marie-Tooth disease progression. Ann Neurol. 2021;89(3):556-568.
Rossi S, Carrier M, Laurá M. Meta-analysis of genetic testing strategies in inherited neuropathies. J Peripher Nerv Syst. 2023;28(1):34-48.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy