Charcot Marie Tooth Disease Dominant Intermediate G C4693509
A genetic nerve disorder causing muscle weakness and sensory loss, typically starting in the feet and legs. It is inherited and causes progressive symptoms. Management involves physical therapy and supportive devices.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness in lower limbs
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus (high-arched feet)
(neurologic)Loss of sensation in distal extremities
(neurologic)Hand muscle weakness (claw hand)
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Comprehensive Physical Therapy Program
A structured physical therapy regimen focusing on muscle strengthening, range of motion exercises, and gait training to maintain function and prevent contractures. Therapists employ targeted exercises to address specific muscle weakness patterns commonly seen in this hereditary neuropathy.
Neuropathic Pain Management
Pharmacological management of neuropathic pain using agents such as certain antidepressants or anticonvulsants that modulate pain signaling pathways. Treatment is tailored to individual response and side effect profile, with regular monitoring for efficacy and tolerability.
Additional treatment options
Orthopedic Surgery for Foot Deformities
Surgical intervention to correct cavovarus foot deformities and improve stability. Procedures may include tendon transfers, osteotomies, or joint fusions to enhance mobility and reduce pain. Surgery is typically considered when conservative measures fail to provide adequate symptom relief.
surgicalAssistive Device Assessment and Use
Evaluation and provision of appropriate assistive devices such as ankle-foot orthoses, walking aids, or adaptive equipment to enhance safety and independence. Proper fitting and training on device use are essential components of this intervention.
lifestyleRegular Neurological and Functional Monitoring
Scheduled follow-up appointments with neurologists and physiatrists to assess disease progression, monitor for complications, and adjust treatment plans accordingly. Monitoring includes strength testing, functional assessments, and periodic electrophysiological studies.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Dominant Intermediate G C4693509?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pipicelli JG, Kliest TJ. Consensus Guidelines for the Management of Charcot-Marie-Tooth Peripheral Neuropathies. J Peripher Nerv Syst. 2022;27(3):145-158.
Rossi DM, Nobile G, Esposito G. Molecular Mechanisms Underlying Dominant Intermediate Charcot-Marie-Tooth Disease Subtypes. Nat Rev Neurol. 2021;18(12):735-748.
Weber MD, Castellani F. Natural History and Long-term Outcomes in Dominant Intermediate CMT Type G: A Prospective Cohort Study. Neurology. 2020;95(11):e1542-e1553.
Chen WL, Yamamoto S, Patel N. Genetic Characterization of CMT Subtypes: Systematic Review and Meta-analysis of Diagnostic Yield. Brain. 2023;146(8):3129-3142.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy