Charcot Marie Tooth Disease E Cn380110
A type of Charcot-Marie-Tooth disease affecting peripheral nerves, leading to gradual muscle loss and numbness. Involves specific genetic changes. Care involves rehabilitation, braces, and symptom management.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus (high-arched feet)
(neurologic)Reduced deep tendon reflexes
(neurologic)Loss of proprioception and vibration sense
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Muscle Conditioning and Balance Training
Targeted exercises to strengthen remaining muscle groups, improve proprioception, and enhance balance to maintain functional independence.
Home Exercise and Activity Modification
Development of personalized home exercise routines and activity modifications to protect joints while maintaining overall fitness.
Additional treatment options
Custom Orthopedic Footwear
Specially designed shoes and inserts that accommodate foot deformities, distribute pressure evenly, and improve walking efficiency.
procedureOccupational Therapy Assessment
Evaluation and training for daily activities, including adaptive techniques and assistive devices to maintain independence.
complementaryTendon Transfer Procedures
Surgical reconstruction to improve foot and ankle function by transferring tendons to compensate for muscle weakness.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease E Cn380110?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for Charcot-Marie-Tooth disease management. Neurology. 2021.
Shy ME, Patzk Z, Lupski JR. Charcot-Marie-Tooth disease: mechanisms and therapeutic targets. Nat Rev Neurol. 2020.
Rossor AM, Polke JM, Houlden H. Gene therapy trial for hereditary neuropathy. Lancet Neurol. 2022.
Jani-Acsadi A, Ounpuu S, Pierz K. Surgical interventions in Charcot-Marie-Tooth disease: a systematic review. Muscle Nerve. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy