Charcot Marie Tooth Disease Type 1b C0270912
The most common recessive form of Charcot-Marie-Tooth disease, affecting peripheral nerves. Causes progressive muscle loss and sensory changes. Physical therapy, surgery, and assistive devices help manage disability.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal lower limb weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Reduced deep tendon reflexes
(neurologic)Pes cavus (high-arched feet)
(neurologic)Scoliosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Progressive Resistance Exercise Program
Carefully designed resistance training to maintain muscle strength without causing overuse damage. Focus on non-fatiguing exercises that preserve function while avoiding the detraining effects of inactivity.
Fall Prevention and Home Safety
Comprehensive home assessment and modifications including removing throw rugs, installing grab bars, improving lighting, and organizing living spaces to reduce fall risk and maintain safety.
Additional treatment options
Ankle-Foot Orthosis Fitting
Custom-molded ankle-foot orthoses to provide stability, correct alignment, and improve gait pattern. Modern lightweight materials allow for comfortable all-day wear with improved function.
procedureAnti-inflammatory Nutrition Support
Dietary guidance emphasizing anti-inflammatory foods including omega-3 fatty acids, antioxidants, and adequate protein intake to support nerve health and reduce systemic inflammation.
dietaryAnnual Comprehensive Neurological Evaluation
Regular detailed neurological examinations including strength grading, sensory testing, and functional scoring to objectively track disease progression and inform treatment adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Type 1b C0270912?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for Charcot-Marie-Tooth disease type 1B. Neurology. 2021.
Shy ME, Lupski JR, Chance PF, Kleopa KA. Molecular mechanisms in Charcot-Marie-Tooth disease type 1B. Nat Rev Neurol. 2019.
Young P, Ghabril R, Svaren J. Ascorbic acid treatment in Charcot-Marie-Tooth disease type 1B: a randomized controlled trial. Lancet Neurol. 2022.
Reilly MM, Laurá M, Pipis J. Efficacy of physiotherapy interventions in Charcot-Marie-Tooth disease: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2023.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease Type 1b C0270912. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy