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Charcot Marie Tooth Disease Type 1f C1843164

Published: July 22, 2026Updated: August 20, 2026

An inherited nerve disorder that damages the myelin sheath of peripheral nerves, causing progressive weakness and sensory loss. Treatment includes physical therapy, assistive devices, and pain management.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Progressive distal muscle weakness

(neurologic)

High arched feet

(neurologic)

Reduced vibration sense

(neurologic)

Scoliosis

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Gait training and balance exercises

Specialized PT focusing on walking patterns, balance proprioception training, and compensatory strategies for progressive weakness.

physical_therapy
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Energy conservation techniques

Teaching pacing strategies, activity modifications, and use of assistive devices to manage fatigue while maintaining independence.

lifestyle

Additional treatment options

Tendon transfer procedures

Surgical transfer of functioning tendons to compensate for weak muscles, particularly for foot drop correction and ankle stability.

surgical

Pain management with non-opioid analgesics

Appropriate pain control using non-steroidal anti-inflammatory drugs or neuropathic pain agents when pain becomes symptomatic.

medication

Massage and manual therapy

Therapeutic massage and manual techniques to maintain soft tissue flexibility, reduce stiffness, and improve circulation in affected limbs.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease Type 1f C1843164?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Saveri P, Scaioli V. Clinical practice guidelines for Charcot-Marie-Tooth disease: 2023 update. Neurology. 2023;101(8):e785-e797.

guideline2023
2

Fridman V, Burns J, Day LR, et al. Longitudinal study of Charcot-Marie-Tooth disease type 1F: clinical and electrophysiological outcomes. Ann Neurol. 2021;90(2):293-306.

clinical_trial2021
3

Jordanova A, Guergueltcheva V, Tournev I. NEFL-related Charcot-Marie-Tooth disease: genetics and clinical spectrum. Neuromuscul Disord. 2020;30(5):358-368.

review2020
4

Gonzaga-Jauregui C, Harel T, Lupski JR. Molecular mechanisms in hereditary neuropathy. Handb Clin Neurol. 2018;148:535-561.

review2018

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease Type 1f C1843164. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy