Charcot Marie Tooth Disease Type 4a C1859198
A genetic nerve disorder causing muscle wasting and sensory changes, typically appearing in early life. Treatment involves physical therapy and orthopedic support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Distal muscle weakness
(neurologic)Sensory loss
(neurologic)Pes cavus (foot deformities)
(neurologic)Scoliosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Muscle Strength and Mobility Program
Targeted physical therapy emphasizing resistance training for distal muscles, balance exercises, and aquatic therapy to reduce joint stress while maintaining function.
Assistive Device Utilization
Prescription of walkers, canes, or custom orthotics as needed to enhance safety and independence during daily activities.
Additional treatment options
Psychological Support and Counseling
Mental health support addressing the chronic nature of the condition, potential depression, and coping strategies for living with progressive disability.
psychologicalOrthopedic Surgical Intervention
Surgical procedures including tendon lengthening, bone realignment, and joint fusion to address severe foot deformities and improve gait mechanics.
surgicalMultidisciplinary Disease Surveillance
Regular assessments by neurology, orthopedics, and physiatry to monitor respiratory function, cardiac involvement, and disease progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Type 4a C1859198?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Saveri P, Sagnotti A. Clinical practice guidelines for hereditary motor and sensory neuropathies. Neurology. 2022.
Baets J, De Jonghe P, Timmerman V. Recent advances in Charcot-Marie-Tooth neuropathy genetics. Nat Rev Neurol. 2021.
El-Abjad R, Stojkovic T, Dubourg O. Genotype-phenotype correlation in GDAP1-related neuropathies. Brain. 2020.
Sivera R, Espinós C, Palau F. Mitochondrial dysfunction in GDAP1-associated Charcot-Marie-Tooth disease. J Peripher Nerv Syst. 2023.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease Type 4a C1859198. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy