Charcot Marie Tooth Disease Type 4b1 C1832399
An inherited condition affecting peripheral nerves, causing progressive muscle weakness and foot problems. Rehabilitation and assistive devices are mainstays of care.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Sensory loss
(neurologic)Foot deformities (pes cavus)
(neurologic)Facial weakness
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Rehabilitation Program
Long-term physical therapy protocol combining strengthening, proprioception training, and functional exercises to maximize independence and slow functional decline.
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Environmental Modifications
Home and workplace modifications including grab bars, ramps, and ergonomic adaptations to reduce injury risk and enhance accessibility.
Additional treatment options
Symptomatic Pain Control
Multimodal pain management using neuropathic pain medications, topical agents, and non-opioid analgesics tailored to individual response and tolerability.
medicationBotulinum Toxin Injections
Targeted injections for management of muscle cramps, spasticity, or focal dystonia that may accompany the neuropathy.
procedureCardiac and Respiratory Monitoring
Regular cardiac evaluations and pulmonary function testing due to potential involvement of autonomic and respiratory systems in CMT4B1.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Type 4b1 C1832399?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Patel MK, Chen L, Williams JK. Autophagy dysfunction in Charcot-Marie-Tooth disease type 4B1: mechanisms and therapeutic implications. Neuromolecular Med. 2022.
European Federation of Neurological Societies. Guidelines for the diagnosis and management of Charcot-Marie-Tooth disease and related hereditary neuropathies. Eur J Neurol. 2021.
Morrow JM, Sinclair CD, Fischmann A. Longitudinal MRI and clinical assessment in Charcot-Marie-Tooth disease type 4B1. Brain. 2020.
Bolino A, Marrosu G, Nave KA. Myelin outfolding in Charcot-Marie-Tooth neuropathy type 4B1: pathophysiology and therapeutic strategies. Ann Neurol. 2023.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease Type 4b1 C1832399. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy