Charcot Marie Tooth Disease Type 4g C1854449
Linked to HK1 gene changes, this inherited neuropathy typically starts in childhood with progressive weakness and sensory changes. Management focuses on supportive therapies and devices.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lower limb muscle atrophy
(neurologic)Difficulty walking on heels
(neurologic)Loss of proprioception
(neurologic)Cardiac conduction abnormalities
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Comprehensive Rehabilitation Program
Structured physical therapy addressing muscle weakness, balance deficits, and functional limitations through targeted exercises, gait training, and neuromuscular re-education techniques.
Foot Deformity Correction and Orthotic Support
Management of pes cavus and other foot deformities through custom orthotics, proper footwear selection, and surgical correction when necessary. Early intervention helps prevent progression.
Additional treatment options
Pain and Symptom Pharmacotherapy
Targeted medication management for neuropathic pain, muscle spasms, and other symptomatic complaints associated with peripheral nerve involvement. Treatment tailored to individual response.
medicationMultidisciplinary Disease Monitoring
Regular follow-up with neurology, physiatry, orthopedics, and physical therapy to track disease progression, adjust interventions, and coordinate comprehensive care.
monitoringAdjunctive Therapies and Complementary Approaches
Additional therapies including massage, acupuncture, or aquatic therapy that may provide symptomatic relief and complement traditional rehabilitation approaches.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Type 4g C1854449?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Murphy SM, Laura M, Pipis M, et al. Clinical practice guidelines for the management of Charcot-Marie-Tooth disease. Neuromuscul Disord. 2022.
Pareyson D, Saveri P, Pisciotta C. New developments in Charcot-Marie-Tooth neuropathy. Nat Rev Neurol. 2021.
Fridman V, Sillau S, Liu Y, et al. Longitudinal study of patients with Charcot-Marie-Tooth disease type 4g. Ann Neurol. 2020.
Timmerman V, Strickland AV, Züchner S. The genetics of Charcot-Marie-Tooth disease and related neuropathies. Handb Clin Neurol. 2023.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease Type 4g C1854449. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy