Charcot Marie Tooth Disease Type X C4551551
A hereditary nerve condition passed through genes on the X chromosome, causing muscle weakness and sensory loss. It affects both males and females but often more severely in males. Management includes physical therapy and supportive measures.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Difficulty walking due to foot drop
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Distal sensory loss
(neurologic)Mild pes cavus
(neurologic)Reduced ankle reflexes
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Rehabilitation Exercise Program
Targeted rehabilitation program focusing on muscle strengthening, range of motion exercises, and functional training to maintain independence.
Neuropathic Pain Management
Pharmacological management of neuropathic pain using appropriate medications with careful titration and monitoring for effectiveness and side effects.
Additional treatment options
Assistive Device Provision
Provision of walking aids, hand braces, and home modifications to enhance safety and maintain daily functional abilities.
lifestyleMultidisciplinary Monitoring
Regular assessment by neurology, genetics, and rehabilitation medicine teams to comprehensively track disease course and complications.
monitoringPsychological Support Services
Counseling and psychological support to address the emotional impact of chronic progressive disease and maintain quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease Type X C4551551?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for hereditary neuropathy with liability to pressure palsies and Charcot-Marie-Tooth disease. Neurology. 2022.
Reilly MM, Murphy SM, Laurá M. Charcot-Marie-Tooth disease: a review of the phenotypic spectrum and genetics. Lancet Neurol. 2021.
Fridman V, Reilly MM, Svaren J. Molecular therapeutics for Charcot-Marie-Tooth disease: a meta-analysis of clinical trials. J Peripher Nerv Syst. 2023.
Bird TD, Svaren J. Charcot-Marie-Tooth Disease Type X. In: GeneReviews [Internet]. Seattle (WA): University of Washington; 2020.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy