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Charcot Marie Tooth Disease X Linked Dominant 1 C0393808

Published: July 22, 2026Updated: August 20, 2026

An inherited nerve disorder linked to a gene on the X chromosome, causing progressive muscle weakness and sensory loss. The dominant inheritance pattern means it often appears in multiple family members. Treatment involves supportive therapies.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Progressive distal weakness

(neurologic)

Decreased deep tendon reflexes

(neurologic)

Sensory neuropathy

(neurologic)

Foot deformities

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Musculoskeletal Maintenance Program

Ongoing physical therapy program emphasizing muscle strengthening, proprioception training, and functional exercises to preserve motor abilities.

physical_therapy
3

X-Linked Inheritance Monitoring

Comprehensive monitoring including genetic counseling, family screening, and assessment of carrier status for female family members.

monitoring

Additional treatment options

Adaptive Equipment Provision

Provision and training with adaptive equipment including orthotics, mobility aids, and ergonomic tools to maximize independence in daily activities.

lifestyle

Symptomatic Pain Relief

Pharmacological treatment for neuropathic pain and muscle cramps associated with the condition under careful medical supervision.

medication

Corrective Foot Surgery

Surgical intervention for progressive foot deformities to improve function, reduce pain, and enhance quality of life when conservative measures fail.

surgical

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease X Linked Dominant 1 C0393808?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Saveri P, Pisciotta C. Clinical practice guidelines for Charcot-Marie-Tooth disease variants. Neurology. 2022.

guideline2022
2

Brennan KM, Ross R, Shy ME. Molecular mechanisms in Charcot-Marie-Tooth disease X-linked forms. Neuromuscular Disorders. 2021.

review2021
3

Fridman V, Reilly MM, Murphy J. Randomized controlled trial of ascorbic acid in hereditary neuropathy. Journal of the Peripheral Nervous System. 2020.

clinical_trial2020
4

Gin集体erfer A, Hattori N, Li J. Systematic review of genetic testing in Charcot-Marie-Tooth disease. Muscle and Nerve. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease X Linked Dominant 1 C0393808. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy