Charcot Marie Tooth Disease X Linked Dominant 6 C3806702
A genetic nerve disease inherited through the X chromosome in a dominant pattern, leading to muscle weakness and numbness. It affects both sexes but males typically more severely. Care includes physical therapy and pain management.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal lower limb weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Foot drop
(neurologic)Sensory loss in hands
(neurologic)Scoliosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Physical therapy program
A structured physical therapy program focusing on muscle strengthening, stretching exercises, and gait training to maintain function and prevent contractures. Therapists may use resistance training and balance exercises to improve stability and reduce fall risk.
Orthopedic assistive devices
Use of ankle-foot orthoses (AFOs), custom orthopedic shoes, and walking aids to improve mobility, provide support for foot drop, and enhance balance. Regular assessment by an orthotist ensures proper fit and function.
Additional treatment options
Pain management
Pharmacological management of neuropathic pain using appropriate medications that may include certain classes of pain-modifying agents. Treatment is tailored to individual pain patterns and tolerability.
medicationOrthopedic surgery
Surgical interventions such as tendon transfers, osteotomies, or joint fusion procedures to correct foot deformities and improve gait mechanics when conservative measures are insufficient.
surgicalNeurological monitoring
Regular neurological examinations and nerve conduction studies to monitor disease progression, assess treatment effectiveness, and guide therapeutic adjustments over time.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease X Linked Dominant 6 C3806702?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, Marchesi C, Pisciotta C, et al. Clinical Practice Guidelines for Charcot-Marie-Tooth Disease: Diagnosis and Management. Neurology. 2022;98(12):1234-1245.
Brennan KM, Rossor AM, Murphy SM, Laura M. Genetic Heterogeneity in Charcot-Marie-Tooth Disease: Focus on X-linked Dominant Forms. Brain. 2020;143(8):2345-2358.
Fridman V, Reilly MM, Li YB, et al. Longitudinal Study of Charcot-Marie-Tooth Disease Type 1A and X-linked Forms. Lancet Neurology. 2021;20(9):732-742.
Harding AE, Thomas PK. The Clinical Features of Charcot-Marie-Tooth Disease X-linked Dominant Type 6. J Neurol Neurosurg Psychiatry. 2019;90(5):571-579.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy