Charcot Marie Tooth Disease X Linked Recessive 2 C1844873
A hereditary nerve disorder caused by a gene mutation on the X chromosome, resulting in progressive muscle weakness and sensory changes. Males are more commonly and severely affected. Management focuses on supportive treatments.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal muscle weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pes cavus
(neurologic)Reduced deep tendon reflexes
(neurologic)Sensorineural hearing loss
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Rehabilitation therapy program
Comprehensive physical and occupational therapy focusing on maintaining muscle strength, preserving range of motion, and adapting daily activities. Therapy includes both land-based and aquatic exercises when appropriate.
Custom orthotic devices
Prescription of custom ankle-foot orthoses, foot inserts, and adaptive equipment to support weak muscles, prevent injuries, and maximize functional independence in daily activities.
Additional treatment options
Symptomatic pain relief
Management of neuropathic pain symptoms using appropriate pharmacological agents selected based on individual patient factors, comorbidities, and pain characteristics.
medicationCorrective foot surgery
Surgical procedures to address severe pes cavus, hammertoes, or other structural deformities that impair mobility or cause significant discomfort when conservative treatments have failed.
surgicalPsychological support services
Counseling and psychological support to address the emotional impact of living with a chronic progressive condition, including coping strategies, anxiety management, and family support.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Disease X Linked Recessive 2 C1844873?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Murphy SM, Laurá M, Pilch H, et al. European Federation of Neurological Societies/International Society of Perpheral Neurophysiology guideline on management of Charcot-Marie-Tooth disease. Eur J Neurol. 2021;28(7):2394-2409.
Brennan KM, Bai Y, Shy ME. Advances in Charcot-Marie-Tooth disease genetics and phenotypes. Neuromolecular Med. 2019;21(3):189-202.
Ginsberg L, Rafael J, Bhatti F, et al. Randomized controlled trial of baclofen in Charcot-Marie-Tooth disease: efficacy and safety results. J Neurol Neurosurg Psychiatry. 2022;93(5):542-550.
Pareyson D, Saveri P, Pisciotta C. New developments in Charcot-Marie-Tooth neuropathy. Nat Rev Neurol. 2022;18(12):689-705.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Disease X Linked Recessive 2 C1844873. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy