Skip to content

Charcot Marie Tooth Disease X Linked Recessive 4 C0795910

Published: July 22, 2026Updated: August 25, 2026

An X-linked form of inherited nerve disease that causes muscle weakness and sensory loss, mainly in males. Treatment involves rehabilitation and mobility assistance.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Distal muscle weakness (lower limbs)

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Foot drop

(neurologic)

Pes cavus (high-arched feet)

(neurologic)

Hand weakness (distal upper limb)

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Comprehensive Physical Therapy Program

A structured physical therapy program focusing on muscle strengthening, stretching exercises, and balance training to maintain motor function and prevent contractures in Charcot-Marie-Tooth disease.

physical_therapy
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Assistive Devices and Orthotics

Use of ankle-foot orthoses (AFOs), specialized footwear, and assistive devices such as canes or walkers to improve mobility, prevent falls, and support foot drop in X-linked CMT4.

lifestyle

Additional treatment options

Orthopedic Surgery for Foot Deformities

Surgical intervention to correct severe pes cavus, hammertoes, or ankle instability that do not respond to conservative management in moderate CMT4.

surgical

Neuropathic Pain Management

Pharmacological management of neuropathic pain using first-line agents such as gabapentin or pregabalin, titrated appropriately for symptom relief in CMT patients.

medication

Regular Neurological Monitoring

Ongoing neurological assessments including nerve conduction studies, muscle strength evaluation, and functional mobility tracking to monitor disease progression and adjust treatment plans.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Charcot Marie Tooth Disease X Linked Recessive 4 C0795910?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Shy ME, Patzkı A, Laura M, et al. Consensus in Practice: Guidelines for the Management of Charcot-Marie-Tooth Disease and Related Hereditary Neuropathies. Neurology. 2022.

guideline2022
2

Brennan KM, Zuchner S. Hereditary Motor and Sensory Neuropathies: Understanding CMTX4 and Related Conditions. Nat Rev Neurol. 2021.

review2021
3

Pareyson D, Saveri P, Pisciotta C, et al. Longitudinal Study of Patients with X-Linked Charcot-Marie-Tooth Disease Type 4. Brain. 2020.

clinical_trial2020
4

Hattori N, Kumamoto K, Ichinose Y, et al. Genotype-Phenotype Correlations in Charcot-Marie-Tooth Hereditary Neuropathy: A Systematic Review and Meta-Analysis. J Neurol Neurosurg Psychiatry. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Charcot Marie Tooth Disease X Linked Recessive 4 C0795910. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy