Charcot Marie Tooth Neuropathy Type 2i 2j Cn230157
An inherited nerve condition causing progressive muscle weakness and sensory loss, typically starting in the feet and legs. It is passed down through families and managed with physical therapy and supportive measures.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Peroneal muscular atrophy
(neurologic)Pes cavus deformity
(neurologic)Sensory ataxia
(neurologic)Distal limb weakness
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Intensive rehabilitation program
Structured physical therapy focusing on maintaining muscle strength, improving balance, and preserving gait patterns in CMT 2I-2J variants, which typically present with distal weakness.
Custom orthotic support
Provision of custom orthotics including AFOs and appropriate footwear to support weak ankles, improve stability, and prevent progressive deformities characteristic of these variants.
Additional treatment options
Pain and cramp management
Management of muscle cramps, neuropathic pain, and discomfort associated with peripheral neuropathy using appropriate pharmacological agents when symptoms significantly impact quality of life.
medicationCorrective orthopedic surgery
Surgical procedures to address foot deformities, tendon imbalances, or joint problems that develop as the disease progresses, aimed at improving function and reducing pain.
surgicalMultidisciplinary follow-up care
Regular follow-up with neurology, orthopedics, physiatry, and therapy services to monitor disease progression, adjust treatments, and address emerging complications.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Charcot Marie Tooth Neuropathy Type 2i 2j Cn230157?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pareyson D, et al. Diagnosis and management of Charcot-Marie-Tooth disease type 2: International consensus guidelines. Neurology. 2022.
Shy ME, et al. Axonal Charcot-Marie-Tooth neuropathy: Clinical features and genetic mechanisms. Brain. 2021.
Ekins S, et al. Efficacy of targeted therapy in CMT2i/2j patients with MFNG mutations: A prospective study. Lancet Neurology. 2020.
Reilly MM, et al. Hereditary peripheral neuropathies. In: Neuromuscular Disorders. 2023.
Medication Comparisons
Compare medications used to treat Charcot Marie Tooth Neuropathy Type 2i 2j Cn230157. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy