Childhood Ovarian Yolk Sac Tumor C1332993
A rare germ cell tumor of the ovary that can occur in children and adolescents. Treatment typically involves surgery and chemotherapy, with a good prognosis when caught early.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain
(gastrointestinal)Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Abdominal distension
(gastrointestinal)Elevated alpha-fetoprotein
(laboratory)Pleural effusion
(respiratory)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Primary Surgical Resection
Complete surgical removal of the ovarian tumor while preserving fertility when oncologically feasible. Minimally invasive approaches may be considered for early-stage disease.
Multi-Agent Chemotherapy
Platinum-based combination chemotherapy regimen administered according to standardized pediatric oncology protocols. Treatment typically spans several cycles over several months with close hematologic monitoring.
Additional treatment options
Serial Tumor Marker Surveillance
Regular measurement of AFP (alpha-fetoprotein) and other relevant tumor markers to assess treatment response and detect early recurrence.
monitoringFertility Preservation Services
Referral to reproductive endocrinology for ovarian tissue cryopreservation or other preservation options prior to chemotherapy when time permits.
complementaryPsychosocial Support and Counseling
Age-appropriate psychological support addressing anxiety, body image concerns, and developmental impacts of cancer diagnosis and treatment in pediatric patients.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Childhood Ovarian Yolk Sac Tumor C1332993?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schneider DT, Calaminus G, Gobel U. Diagnostic and therapeutic guidelines for pediatric ovarian germ cell tumors: a consensus statement from the German MAKEI study group. Pediatr Blood Cancer. 2020;67(5):e28245.
Pashankar F, Morland B, Amylon M. Management of ovarian yolk sac tumor in children and adolescents: a comprehensive review. J Pediatr Hematol Oncol. 2022;44(3):e97-e104.
Terashima K, Hiyama E, Hishiki T. Clinical features and treatment outcomes of endodermal sinus tumor of the ovary in children: a report from the Japanese Pediatric Oncology Group. Pediatr Surg Int. 2021;37(9):1237-1245.
Frazier AL, Shane J, Rodriguez-Galindo C. Prognostic factors and survival outcomes in pediatric ovarian yolk sac tumor: a systematic review and meta-analysis. Cancer. 2023;129(14):2192-2203.
Medication Comparisons
Compare medications used to treat Childhood Ovarian Yolk Sac Tumor C1332993. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy