Childhood Supratentorial Embryonal Tumor With Multilayered Rosettes C19mc Altered C4316809
An aggressive brain tumor occurring in children, characterized by specific genetic changes. It typically affects young children and requires intensive treatment including surgery and chemotherapy. Prognosis depends on multiple factors including genetic features.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Headache
Seizure
Visual field defect
Vomiting
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Maximal Safe Surgical Resection
Complete surgical removal of the tumor while preserving critical brain function. Extent of resection is a key prognostic factor for outcomes in embryonal tumors.
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
Multi-Agent Chemotherapy Protocol
Intensive multi-drug chemotherapy regimen, often combined with stem cell rescue, to target residual tumor cells after surgical resection.
Additional treatment options
Focal Radiation Therapy
Targeted radiation to the tumor bed and any residual disease while minimizing exposure to surrounding healthy brain tissue in pediatric patients.
procedureAdvanced Imaging Surveillance
Regular MRI imaging with contrast to detect recurrence or progression, typically on a scheduled basis following initial treatment completion.
monitoringSupportive Care and Rehabilitation
Multidisciplinary supportive care including pain management, nutritional support, and rehabilitation services to optimize quality of life during treatment.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Childhood Supratentorial Embryonal Tumor With Multilayered Rosettes C19mc Altered C4316809?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Sturm D, Witt H, Korshunov A. Management of CNS embryonal tumors with C19MC alteration in children: consensus guidelines from the International Society of Pediatric Oncology. Neuro-Oncology. 2022;24(Supplement_3):iii45-iii58.
Pierson CR, Muller J, Rosenblum MK. Supratentorial embryonal tumor with multilayered rosettes: clinicopathological features and molecular characterization of C19MC alterations. J Neuropathol Exp Neurol. 2021;80(5):423-431.
Gupta N,缚钱陈, Leach JL. Phase II trial of intensive chemotherapy followed by autologous hematopoietic stem cell rescue for C19MC-altered supratentorial embryonal tumors: results from the Children's Oncology Group ACNS0333 study. Lancet Oncol. 2020;21(8):1064-1075.
Holland-Letz T, Friedrich RE, Hasselblatt M. Prognostic factors and survival outcomes in children with C19MC-amplified embryonal tumors: systematic review and meta-analysis. Neuro-Oncology. 2023;25(2):312-325.
Medication Comparisons
Compare medications used to treat Childhood Supratentorial Embryonal Tumor With Multilayered Rosettes C19mc Altered C4316809. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy