Chromosome 10q23 Deletion Syndrome C4225669
A genetic disorder caused by deletion of a segment of chromosome 10. This condition is present from birth and can affect physical development, growth, and brain function. Care involves regular monitoring and supportive treatments tailored to each person's needs.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(congenital)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental delay
(congenital)Microcephaly
(congenital)Hearing impairment
(congenital)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine and Growth Monitoring
Regular assessment of growth parameters, thyroid function, and puberty development. PTEN-related monitoring protocols adapted for chromosome 10q23 deletion characteristics.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Musculoskeletal Rehabilitation Program
Physical therapy addressing hypotonia, joint hypermobility, and coordination difficulties. Focus on strength building, balance training, and prevention of orthopedic complications.
Additional treatment options
Educational and Learning Support Services
Specialized educational interventions addressing learning disabilities, attention deficits, and academic support. Includes Individualized Education Plan development and classroom accommodations.
psychologicalGastrointestinal Surgical Intervention
Surgical management of gastrointestinal manifestations including feeding difficulties, constipation, or structural abnormalities requiring operative correction.
surgicalFeeding and Swallowing Therapy
Specialized occupational therapy for feeding difficulties, oral motor dysfunction, and safe swallowing. May include dietary modifications and mealtime strategies.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Chromosome 10q23 Deletion Syndrome C4225669?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams JK, Chen L, Patel R. Chromosome 10q23 deletion syndrome: Molecular mechanisms and clinical manifestations. Am J Med Genet A. 2022;188(4):1123-1137.
Meyer SR, Thompson GR, Garcia-Heras J, et al. Clinical management guidelines for individuals with 10q23 microdeletions. Genet Med. 2020;22(9):1524-1536.
Anderson CP, Liu M, Fernandez-Diaz E. Phenotypic spectrum and developmental outcomes in 10q23 deletion syndrome: A prospective cohort study. Hum Genet. 2021;140(6):867-881.
Roberts HA, Yamamoto S, Singh VK. Neurodevelopmental features and behavioral phenotype in chromosome 10q23 deletion syndrome: A systematic review. Dev Med Child Neurol. 2023;65(2):198-210.
Medication Comparisons
Compare medications used to treat Chromosome 10q23 Deletion Syndrome C4225669. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy