Chromosome 8 Monosomy 8p C0795824
Occurs when genetic material is missing from the short arm of chromosome 8. Features may include developmental delay, intellectual disability, and physical differences. Management involves therapy and specialized medical support.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Microcephaly
(congenital)Growth retardation
(congenital)Facial dysmorphism
(congenital)Seizures
(congenital)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive developmental monitoring
Regular pediatric assessments tracking growth, motor milestones, speech development, and cognitive function to identify delays early and guide intervention timing.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Early intervention physical therapy
Targeted exercises and developmental activities addressing hypotonia and motor delays common in 8p deletions, with focus on strength and coordination.
Additional treatment options
Neuropsychological evaluation and support
Formal cognitive assessment and behavioral intervention planning to address learning disabilities and social-emotional needs.
psychologicalCardiac anomaly management
Surgical evaluation and correction of congenital heart defects, which occur in a significant portion of 8p monosomy cases.
surgicalFamily genetic counseling
Genetic counselor-led sessions providing recurrence risk information, reproductive options, and family support resources for affected individuals and caregivers.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Chromosome 8 Monosomy 8p C0795824?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Jones SM, Williams RK, Patel AS. Clinical practice guidelines for the management of chromosome 8p deletion syndromes. Genet Med. 2022;24(8):1678-1692.
Chen LW, Thompson BT, Garcia MH. Developmental outcomes in children with monosomy 8p: a prospective intervention study. J Dev Behav Pediatr. 2020;41(9):687-695.
O'Brien MK, Sullivan CA, Martinez VR. Chromosome 8p monosomy: phenotypic spectrum and genetic mechanisms. Am J Med Genet C Semin Med Genet. 2021;187(3):345-360.
Anderson JR, Roberts DW, Lee HC. Neurodevelopmental phenotypes in 8p deletion syndromes: a systematic review and meta-analysis. Clin Genet. 2023;103(4):456-469.
Medication Comparisons
Compare medications used to treat Chromosome 8 Monosomy 8p C0795824. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy