Chronic Idiopathic Urticaria C0578870
Recurring hives that persist for weeks with no identifiable trigger. Can significantly impact quality of life. Treated with antihistamines and other medications.
Key facts at a glance
- ICD-10
- L98.9
- ICD-11
- EA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Second-generation antihistamines
First-line pharmacotherapy using non-sedating antihistamines that block H1 receptors to reduce itching and hive formation. These are taken regularly rather than as needed for chronic management.
Leukotriene receptor antagonists
Add-on therapy that blocks inflammatory leukotrienes involved in urticaria pathophysiology. Often combined with antihistamines when monotherapy is insufficient.
Additional treatment options
Omalizumab
Monoclonal antibody therapy targeting IgE that is approved for chronic idiopathic urticaria unresponsive to standard antihistamine therapy. Administered as subcutaneous injections.
medicationStress management and relaxation
Techniques including mindfulness, cognitive behavioral approaches, and relaxation training to reduce stress-triggered flares. Chronic urticaria can be exacerbated by psychological stress.
psychologicalTrigger identification and avoidance
Maintaining a symptom diary to identify potential triggers such as temperature changes, certain foods, medications, or physical factors. Systematic avoidance of identified triggers can reduce flare frequency.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Chronic Idiopathic Urticaria C0578870?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy. 2018.
Kaplan AP. Chronic urticaria: pathogenesis and treatment. J Allergy Clin Immunol Pract. 2014.
Sanchez-Borges M, Caballero-Fonseca F, Curo A. Efficacy of omalizumab in chronic urticaria: a systematic review and meta-analysis of randomized clinical trials. J Eur Acad Dermatol Venereol. 2016.
Maurer M, Rosén K, Hsieh HJ, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013.
Medication Comparisons
Compare medications used to treat Chronic Idiopathic Urticaria C0578870. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy