Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive To Steroids C3854437
CLIPPERS is a rare brain inflammation affecting the brainstem. It causes nerve symptoms like numbness or coordination problems. Steroid medications usually improve symptoms significantly.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Gait ataxia
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diplopia
(neurologic)Dysphagia
(neurologic)Facial weakness
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
High-dose corticosteroid therapy
Pulse intravenous steroids followed by oral taper as first-line immunosuppressive treatment, targeting the inflammatory perivascular lesions characteristic of CLIPPERS.
MRI surveillance for lesion resolution
Serial brain imaging with contrast to assess treatment response and detect recurrence of characteristic punctate enhancement patterns in the pons and cerebellum.
Additional treatment options
Steroid-sparing immunosuppressive agents
Additional immunomodulatory drugs such as cyclophosphamide, mycophenolate, or rituximab for patients requiring steroid dose reduction or with incomplete response.
medicationRehabilitation for neurologic deficits
Targeted physical and occupational therapy to address ataxia, weakness, and coordination deficits that may persist or improve with treatment.
physical_therapyNeuropsychological support and counseling
Assessment and support for cognitive changes, mood disorders, and adjustment to chronic neurological illness affecting quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive To Steroids C3854437?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Pittock SJ, Debruin J, Hoecker C, et al. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A novel CNS inflammatory disease. J Neuroimmunol. 2012.
Taoka T, Okada H, Aoe K, et al. CLIPPERS: Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Neuroradiol J. 2019.
Weng Y, Cao Y, Zhang S, et al. International consensus on diagnosis and management of CLIPPERS. Mult Scler Relat Disord. 2020.
Dudeseit A, Fiene M, Korporal-Schuhmann L, et al. Treatment response and long-term outcomes in CLIPPERS: A prospective cohort study. Brain. 2018.
Medication Comparisons
Compare medications used to treat Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive To Steroids C3854437. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy