Skip to content

Chronic Urticaria C0263338

Published: July 22, 2026Updated: August 20, 2026

Long-term hives that occur regularly for six weeks or longer. Can persist for months or years. Treatment aims to control symptoms, often with antihistamines.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
L98.9
ICD-11
EA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

High-dose second-generation antihistamines

Standard-dose second-generation antihistamines as first-line therapy for chronic spontaneous urticaria. Updosing may be considered for refractory cases under medical supervision.

medication
2

Lifestyle modification and dietary intervention

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
3

Omalizumab

Anti-IgE monoclonal antibody therapy for chronic urticaria unresponsive to antihistamines. Binds circulating IgE to reduce mast cell activation and histamine release.

medication

Additional treatment options

Stress management and sleep optimization

Stress reduction techniques including mindfulness, cognitive behavioral therapy, and sleep hygiene improvements may help reduce urticaria flares, as stress can exacerbate symptoms.

lifestyle

Pseudoallergen-free diet trial

Temporary elimination diet removing food additives, preservatives, and high-histamine foods may benefit a subset of patients with food-related urticaria exacerbations.

dietary

Cognitive behavioral therapy

Structured psychological intervention addressing the psychological burden of chronic urticaria including itch-scratch cycles, anxiety, and quality of life impacts associated with visible symptoms.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Chronic Urticaria C0263338?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Zuberbier T, Asero R, Bindslev-Jensen C, et al. The EAACI/GA(2)LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis, and Management of Urticaria. Allergy. 2022;77(9):2689-2706.

guideline2022
2

Sanchez J, Alvarez L, Cardona R. Cyclosporine and omalizumab for chronic urticaria: A systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2020;125(5):543-551.

meta_analysis2020
3

Kaplan AP. Chronic urticaria: Novel concepts in pathogenesis and treatment. J Allergy Clin Immunol Pract. 2021;9(12):4239-4248.

review2021
4

Maurer M, Rosén K, Hsieh MH, et al. Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria. N Engl J Med. 2013;368(10):924-935.

clinical_trial2013

Medication Comparisons

Compare medications used to treat Chronic Urticaria C0263338. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy