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Ciliary Dyskinesia Primary 49 Without Situs Inversus C5774291

Published: July 22, 2026Updated: August 20, 2026

A genetic condition that impairs cilia function throughout the body. Patients often have recurrent sinus and lung infections. Ongoing care focuses on infection management.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
J98.9
ICD-11
CA00.0
Body system
respiratory
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Chronic rhinitis

(respiratory)

Shortness of breath or cough

(respiratory)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Recurrent otitis media

(respiratory)

Bronchiectasis

(respiratory)

Infertility due to immotile sperm

(respiratory)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Chest Physiotherapy and Airway Clearance

Regular chest physiotherapy including postural drainage, percussion, and breathing exercises helps mobilize and clear thick mucus from the airways. This is typically performed 2-4 times daily to maintain airway patency and reduce infection risk.

physical_therapy
2

Respiratory therapy and management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Mucolytic Therapy

Mucolytic agents such as nebulized hypertonic saline help thin and loosen respiratory secretions, making them easier to clear through coughing and airway clearance techniques. This reduces mucus plugging and associated infections.

medication

Additional treatment options

Antibiotic Therapy for Respiratory Infections

Prompt antibiotic treatment of bacterial respiratory infections is essential, as patients are susceptible to chronic infections. Culture-directed therapy is preferred, and prophylactic antibiotics may be considered for recurrent infections.

medication

Pulmonary Function and Infection Surveillance

Regular monitoring of pulmonary function tests and routine cultures to detect early declines in lung function and identify pathogens before clinical exacerbations. Early intervention prevents irreversible lung damage.

monitoring

Surgical Management of Complications

Surgical intervention may be necessary for complications such as nasal polyp removal, sinus surgery, or insertion of ventilation tubes for chronic otitis media. These procedures address anatomical obstructions and improve quality of life.

surgical

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Ciliary Dyskinesia Primary 49 Without Situs Inversus C5774291?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Barbato A, Frischer T, Kuehni CE, et al. Primary ciliary dyskinesia: a consensus statement on diagnostic and treatment approaches in children. Eur Respir J. 2009;34(6):1264-1276.

guideline2009
2

Knowles MR, Daniels LA, Zariwala MA, Leigh MW. Primary ciliary dyskinesia: recent advances in diagnostics, genetics, and characterization of the upper and lower airway tract. Chest. 2013;144(2):631-642.

review2013
3

Shapiro AJ, Davis SD, Polineni D, et al. Analysis of Nasal Nitric Oxide Optimization Study in Primary Ciliary Dyskinesia. Am J Respir Crit Care Med. 2018;197(3):380-392.

other2018
4

Horani A, Ferkol TW, Dutcher SK, Brody SL. Genetics and biology of primary ciliary dyskinesia. Paediatr Respir Rev. 2016;18:18-24.

review2016

Medication Comparisons

Compare medications used to treat Ciliary Dyskinesia Primary 49 Without Situs Inversus C5774291. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy