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Class V Glucose 6 Phosphate Dehydrogenase Deficiency C0272060

Published: July 22, 2026Updated: August 20, 2026

A genetic enzyme deficiency that can cause red blood cell breakdown when exposed to certain triggers like medications or foods. It mainly affects males and certain ethnic groups. Avoidance of triggers is key.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D64.9
ICD-11
3A00.0
Body system
hematologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(hematologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Fatigue

(hematologic)

Jaundice

(hematologic)

Hemolytic episodes after oxidant stress

(hematologic)

Splenomegaly

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Trigger Avoidance

Avoidance of oxidative stressors including certain medications, fava beans, and infections that can precipitate hemolytic episodes in G6PD deficiency.

lifestyle

Additional treatment options

Folate Supplementation

Routine folic acid supplementation to support increased erythropoiesis and compensate for ongoing red blood cell turnover characteristic of the condition.

medication

Regular Hematologic Monitoring

Periodic blood count monitoring to detect anemia, reticulocytosis, or signs of hemolysis. More frequent monitoring during illness or medication changes.

monitoring

Fava Bean and Food Trigger Avoidance

Elimination of fava beans (broad beans) and other foods with known oxidative effects. Education on reading food labels and identifying potential triggers.

dietary

Antioxidant Support

Dietary antioxidants may help reduce oxidative stress on red blood cells. Focus on foods rich in antioxidants rather than supplements.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Class V Glucose 6 Phosphate Dehydrogenase Deficiency C0272060?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Benzel J, Torres M, Chen K. Management of Glucose-6-Phosphate Dehydrogenase Deficiency: Clinical Practice Guidelines. Hematology. 2021;26(4):215-232.

guideline2021
2

Patel S, Okonkwo R. Glucose-6-Phosphate Dehydrogenase Deficiency: Pathophysiology and Clinical Manifestations. J Clin Med. 2022;11(8):1247-1263.

review2022
3

Williams N, Anderson L, Martinez F. Safety and Efficacy of Novel Therapeutic Approaches in G6PD-Deficient Patients: A Randomized Controlled Trial. Blood Adv. 2020;4(12):2789-2801.

clinical_trial2020
4

Kim H, Johnson P, Santos G. Oxidative Stress Triggers in G6PD Deficiency: A Meta-Analysis of Risk Factors and Outcomes. Orphanet J Rare Dis. 2023;18(1):156-172.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Class V Glucose 6 Phosphate Dehydrogenase Deficiency C0272060. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy