Codeine Ultrarapid Metabolism Of C1837160
A genetic variation affecting how quickly the body processes codeine. Individuals with this variation may experience stronger effects from standard codeine doses.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Mild respiratory depression
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Increased drowsiness
(nervous system)Nausea
(gastrointestinal)Constipation
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Codeine avoidance
Complete avoidance of codeine-containing medications as the primary management strategy. Patients should inform all healthcare providers and pharmacists about this genetic predisposition.
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Alternative pain management
Using alternative analgesics such as acetaminophen, ibuprofen, or other non-opioid pain relievers. For conditions requiring opioids, using medications that are not affected by CYP2D6 metabolism.
Additional treatment options
Pharmacogenomic-guided prescribing
Healthcare providers should review pharmacogenomic information before prescribing medications metabolized by CYP2D6. Many drugs besides codeine may be affected by this enzyme polymorphism.
medicationNon-pharmacological pain management
Incorporating physical therapy, acupuncture, cognitive behavioral therapy, or other non-pharmacological approaches to reduce reliance on opioid medications for pain control.
complementaryPatient and family education
Comprehensive education about the genetic basis of ultrarapid metabolism, associated risks with codeine, and importance of communicating this information to healthcare providers and family members.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Codeine Ultrarapid Metabolism Of C1837160?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Crews KR, Gaedigk A, Leeder JS, McLeod HL. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6 and codeine therapy. Clin Pharmacol Ther. 2014.
St Sauver JL, Bielinski SJ, Olson JE, Bell EM, Caravello T, Weinshilboum RM. Pharmacogenomic factors influencing opioid efficacy and adverse events. Pharmacogenomics. 2015.
Feng J, Wang J, Zhang Z, Chen J. Clinical implications of CYP2D6 polymorphisms for codeine metabolism. Pharmacogenomics J. 2018.
Dean L. Codeine Therapy and CYP2D6 Genotype. Med Genet Summ. 2012.
Medication Comparisons
Compare medications used to treat Codeine Ultrarapid Metabolism Of C1837160. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy