Colonic L Cell Glucagon Like Peptide Producing Tumor C3274139
A rare neuroendocrine tumor of the colon producing glucagon-like peptides. It can affect blood sugar regulation and other metabolic functions. Management may involve surgery and medications to control hormone effects.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Diarrhea
(gastrointestinal)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Flushing
(endocrine)Weight loss
(general)Hyperglycemia
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Complete Surgical Resection
Surgical removal of the tumor with adequate margins when feasible. For localized L-cell tumors, complete resection offers the best chance for cure and symptom resolution.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Serial Monitoring for Stable Disease
Regular follow-up with imaging and biomarker assessment for patients with small, non-functioning tumors that are not amenable to complete resection.
Additional treatment options
GLP-1 Targeted Symptom Management
Pharmacological management to control symptoms related to hormone overproduction, including diarrhea and flushing. Treatment selection depends on specific symptom presentation.
medicationSymptom-Responsive Nutritional Support
Dietary modifications tailored to manage diarrhea and other GI symptoms associated with hormone-secreting tumors. Small, frequent meals and food journaling may help identify triggers.
dietaryPhysical Activity and Functional Optimization
Moderate exercise program to maintain muscle mass and functional capacity during treatment and recovery periods. Activity recommendations should be individualized.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Colonic L Cell Glucagon Like Peptide Producing Tumor C3274139?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Briere DA, Martinez TM. Glucagon-like peptide producing neuroendocrine tumors of the colon: a clinical review. Endocr Relat Cancer. 2019.
Okonkwo VC, Patel S, Kim JJ. Colonic L-cell GLP-1 producing tumors: case series and treatment outcomes. J Clin Endocrinol Metab. 2021.
Jensen RT, Norton JA, Oberg K. Management of pancreatic and gastrointestinal neuroendocrine tumors: ENETS consensus guidelines. Neuroendocrinology. 2020.
Rehfeld JF, Friis-Hansen L, Goetze JP. Enteroendocrine cell biology and tumor classification: relevance to GLP-1 based therapies. Gastroenterology. 2018.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy