Combined Apoa I And Apoc Iii Deficiency Cn294815
A rare genetic disorder affecting how the body processes fats. It can lead to abnormal cholesterol levels and increase heart disease risk. Treatment involves diet changes, exercise, and sometimes medications to control lipids.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent pancreatitis
(gastrointestinal)Xanthoma formation
(integumentary)Hepatomegaly
(hepatobiliary)Elevated serum triglycerides
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Specialized lipid-lowering diet
Strict adherence to low-fat, low-carbohydrate diet with emphasis on monounsaturated fats and elimination of simple sugars to address HDL deficiency and hypertriglyceridemia.
Fibrate therapy
Peroxisome proliferator-activated receptor alpha agonists to reduce triglycerides and potentially improve HDL levels in conjunction with dietary modification.
Additional treatment options
Aerobic exercise program
Regular cardiovascular exercise to naturally improve lipid profiles, increase HDL, and reduce cardiovascular risk associated with this deficiency.
lifestyleLipid profile and cardiac monitoring
Frequent lipid panel testing and cardiovascular imaging to monitor disease progression and treatment efficacy.
monitoringOmega-3 fatty acid supplementation
Marine-derived omega-3 supplementation as adjunctive therapy to further reduce triglycerides and provide cardiovascular protection.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Combined Apoa I And Apoc Iii Deficiency Cn294815?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy