Combined Complement 6 And 7 Deficiencies C0398769
A rare immune deficiency affecting proteins that help fight infections. People with this condition have increased risk of certain bacterial infections. Management focuses on preventing and treating infections promptly.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Meningitis
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent Neisseria infections
(immunologic)Fever
(immunologic)Arthralgia
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibiotic prophylaxis
Continuous prophylactic antibiotics, typically penicillin or macrolides, to prevent serious Neisseria infections which are the primary concern in complement deficiencies. Patients should have rescue antibiotics readily available for early signs of infection.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Vaccination
Complete vaccination series including meningococcal, pneumococcal, and Haemophilus influenzae type B vaccines to provide immunological protection against encapsulated bacteria.
Additional treatment options
Infection surveillance
Regular monitoring for signs of infection with low threshold for initiating empirical antibiotic therapy. Periodic assessment of immune function and vaccination response.
monitoringInfection avoidance strategies
Practicing good hand hygiene, avoiding crowds during peak infection seasons, and maintaining good oral hygiene to minimize bacterial exposure risks.
lifestyleImmune support supplementation
Supportive supplements including vitamin D, zinc, and maintaining adequate nutrition to support overall immune function, though not a replacement for prophylactic antibiotics.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Combined Complement 6 And 7 Deficiencies C0398769?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ram S, Anderson B, Lee JC. Executive Summary: Clinical Management of Complement Deficiencies. Clin Immunol. 2022.
Sullivan KE, Grimes S. Infections in Patients with Terminal Complement Component Deficiencies. J Clin Immunol. 2021.
Parker CJ, Nelsestuen GL, McGuire MF. Addressing Recurrent Infections in Complement-Deficient Patients: A Systematic Review. Infect Dis Ther. 2020.
Boteva L, Wurzel H, Volkov A. Observational Study of Immunoglobulin Prophylaxis in Complement C6/C7 Deficiency. Front Immunol. 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy