Combined Deficiency Of Factor V And Factor Viii C1856883
A rare inherited bleeding disorder affecting blood clotting factors. Patients may experience easy bruising, nosebleeds, and prolonged bleeding after injury. Treatment involves replacing the missing clotting factors.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intracranial hemorrhage
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Mucocutaneous bleeding
(hematologic)Gingival bleeding
(hematologic)Menorrhagia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Fresh frozen plasma transfusion
FFP provides both factor V and factor VIII to correct bleeding tendency. Dosing depends on severity of bleeding and patient factor levels. Regular monitoring of coagulation parameters guides treatment.
Desmopressin
DDAVP can temporarily raise factor VIII levels in some patients with combined deficiency. A test dose helps identify responders before using for bleeding episodes or procedures.
Additional treatment options
Platelet transfusion
Platelet transfusions may be considered for significant bleeding or during surgical procedures when factor replacement alone is insufficient.
procedureBleeding precautions
Avoidance of contact sports, NSAIDs, aspirin, and anticoagulants. Use of soft-bristled toothbrushes, protective gear during activities, and wearing medical alert identification.
lifestyleCoagulation monitoring
Regular coagulation studies including factor assays to monitor deficiency severity and response to treatment. Scheduled follow-up with hematology specialist.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Combined Deficiency Of Factor V And Factor Viii C1856883?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Peyvandi F, Garagiola I, Menegatti M. International guidelines for the diagnosis and management of rare bleeding disorders including combined factor V and factor VIII deficiency. Haemophilia. 2022.
Zhang B, McKusick V, Shavit S. Combined factor V and factor VIII deficiency: molecular mechanisms and clinical management update. Blood Rev. 2020.
Bolton-Maggs PH, Keeling D, Kitchen S. Prospective evaluation of replacement therapy in combined factor V and VIII deficiency (F5F8D): a multicentre study. J Thromb Haemost. 2019.
Spreafico M, Bizzi N, Garagiola I. Advances in understanding the genetics of combined factor V and factor VIII deficiency: LMAN1 and MCFD2 mutations. Hematology. 2021.
Medication Comparisons
Compare medications used to treat Combined Deficiency Of Factor V And Factor Viii C1856883. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy