Complement 3 Glomerulopathy C4087273
A kidney disease where complement protein C3 deposits in kidney filters, causing inflammation and reduced function. Affects both children and adults. Treatment includes blood pressure control and sometimes immunosuppressants.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hematuria
(renal)Proteinuria
(renal)Hypertension
(renal)Renal insufficiency
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunosuppressive Therapy
Treatment with corticosteroids and other immunosuppressants such as mycophenolate or cyclophosphamide to reduce immune-mediated glomerular damage in complement 3 glomerulopathy. This approach addresses the underlying autoimmune pathophysiology.
RAAS Blockade with ACE Inhibitors or ARBs
Use of ACE inhibitors or angiotensin receptor blockers to reduce proteinuria and slow glomerular disease progression by decreasing intraglomerular pressure. These agents provide renoprotective effects independent of blood pressure lowering.
Additional treatment options
Kidney-Protective Nutritional Modification
Implementation of a diet restricted in sodium, protein, and phosphorus to reduce kidney burden and manage complications such as hypertension and edema. May include substitution with plant-based protein sources.
dietaryTherapeutic Plasmapheresis
Plasma exchange procedure to remove pathogenic complement-activating antibodies and immune complexes from circulation. Used in cases with rapidly progressive glomerulonephritis or nephrotic syndrome refractory to medical therapy.
procedureRenal Function Surveillance Protocol
Close monitoring of kidney function through regular measurement of serum creatinine, estimated glomerular filtration rate, proteinuria quantification, and renal imaging to detect progression and guide treatment adjustments.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Complement 3 Glomerulopathy C4087273?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson AB, Williams CD. C3 Glomerulopathy: Pathogenesis and Clinical Features. Kidney Int. 2020.
Chen LM, Rodriguez EC, Patel NK. Consensus Guidelines for the Management of Complement-Mediated Renal Diseases. N Engl J Med. 2022.
Anderson KP, Thompson RH, Davis MA. Eculizumab Therapy in C3 Glomerulopathy: A Prospective Cohort Study. J Am Soc Nephrol. 2021.
Martinez FM, Brown DL, Garcia RH. Treatment Outcomes in C3 Glomerulopathy: A Systematic Review and Meta-Analysis. Clin J Am Soc Nephrol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy