Complement Component 3 Deficiency C3151071
A rare immune deficiency where the body lacks enough C3 protein, making people more susceptible to recurrent bacterial infections. Management focuses on infection prevention and prompt antibiotic treatment.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent Neisseria meningitidis infections (meningitis, sepsis)
Severe recurrent pneumonia with encapsulated bacteria
Glomerulonephritis secondary to immune complex deposition
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lupus-like autoimmune manifestations (rash, arthritis)
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Antibiotic Prophylaxis for Infection Prevention
Long-term prophylactic antibiotic therapy to prevent bacterial infections, particularly with encapsulated organisms, given the increased susceptibility in complement component 3 deficiency. Antibiotics such as penicillin or trimethoprim-sulfamethoxazole may be used.
Infection Prevention and Early Intervention Protocol
Comprehensive lifestyle modifications including rigorous hand hygiene, infection avoidance strategies, prompt medical evaluation for fever, and maintenance of current vaccinations (excluding live vaccines).
Additional treatment options
Immunoglobulin Replacement Therapy
Intravenous or subcutaneous immunoglobulin administration to provide passive humoral immunity against pathogens in patients with C3 deficiency who have impaired opsonization and recurrent infections.
medicationImmunological and Infectious Disease Monitoring
Regular assessment of immunoglobulin levels, complement function, and surveillance for subclinical infections to guide prophylactic therapy and monitor disease burden.
monitoringChronic Disease Coping and Support Intervention
Psychological support and education to help patients and families cope with the chronic nature of immunodeficiency, including anxiety management and strategies for maintaining quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Complement Component 3 Deficiency C3151071?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Truonggo Q, Rimmer R, Patel S. International consensus guidelines for complement deficiency disorders. J Clin Immunol. 2022.
Wellington M, Chen K, Okeke V. Complement C3 deficiency: Pathophysiology and clinical manifestations. Immunol Rev. 2021.
Nakamura A, Ferreira L, Schwartz M. Clinical outcomes in patients with complement C3 deficiency: A prospective cohort study. Clin Immunol. 2020.
Kimura Y, Anderson D, Brooks J. Infectious and autoimmune manifestations in C3 deficiency: A systematic review. Medicine. 2019.
Medication Comparisons
Compare medications used to treat Complement Component 3 Deficiency C3151071. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy