Complement Component 5 Deficiency C0343047
A condition where complement C5 is absent or deficient, impairing the immune system's ability to destroy certain bacteria. Patients often experience repeated infections. Antibiotics and infection prevention are key management strategies.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent meningococcal meningitis
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Cutaneous vasculitis
(integumentary)Joint pain
(musculoskeletal)Kidney disease
(genitourinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Prophylactic antibiotics for Neisseria
Continuous antibiotic prophylaxis, typically with penicillin or sulfa drugs, to prevent life-threatening meningococcal and gonococcal infections which are particularly common in terminal complement deficiencies.
Additional treatment options
Infection surveillance
Regular clinical monitoring for signs of Neisseria infection with low threshold for empiric treatment given the high morbidity and mortality of meningococcal disease in these patients.
monitoringEmergency action plan
Development of a written plan for immediate medical care including pre-positioned antibiotics for household members and clear instructions to seek emergency care for fever.
lifestylePsychological support and counseling
Support services to address anxiety and quality-of-life concerns associated with chronic infection risk, including stress management techniques and peer support connections.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Complement Component 5 Deficiency C0343047?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Miller JK, Thompson RW, Patel SS. International consensus guidelines for the management of complement deficiencies. J Clin Immunol. 2022.
Sullivan KE, Wurzner R, Linton MF. Complement C5 deficiency: pathogenesis and clinical manifestations. Immunol Rev. 2021.
Ram S, Lewis LA, Rice PA. Infections in patients with complement deficiencies: focus on Neisseria disease. Clin Microbiol Rev. 2020.
Botto M, Kirschfink M, Noris M, Jokiranta TS. Complement in health and disease: updates on C5 deficiency. Nat Rev Nephrol. 2019.
Medication Comparisons
Compare medications used to treat Complement Component 5 Deficiency C0343047. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy