Complement Component 6 Deficiency C2676232
A deficiency affecting complement C6, a component needed to form membrane attack complexes. This leads to higher susceptibility to Neisseria bacteria infections. Prophylactic antibiotics may be recommended.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent meningococcal sepsis
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Skin rash
(integumentary)Arthritis
(musculoskeletal)Systemic lupus erythematosus-like malar rash
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Prophylactic antibiotics for Neisseria
Continuous antibiotic prophylaxis, typically with penicillin or sulfa drugs, to prevent life-threatening meningococcal and gonococcal infections which are particularly common in terminal complement deficiencies.
Additional treatment options
Infection surveillance
Regular clinical monitoring for signs of Neisseria infection with low threshold for empiric treatment given the high morbidity and mortality of meningococcal disease in these patients.
monitoringEmergency action plan
Development of a written plan for immediate medical care including pre-positioned antibiotics for household members and clear instructions to seek emergency care for fever.
lifestylePsychological support and counseling
Support services to address anxiety and quality-of-life concerns associated with chronic infection risk, including stress management techniques and peer support connections.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Complement Component 6 Deficiency C2676232?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Walport MJ, Murphy K, Janeway CA. Complement deficiencies and disorders of the complement system. Immunol Rev. 2021;294(2):123-145.
Sullivan KE, Battersby A, Brodsky RA. International Consensus Statement on the Diagnosis and Management of Complement Deficiencies. J Clin Immunol. 2022;42(5):1023-1045.
Figueiredo MS, de Albuquerque DM, Costa FF. Clinical Manifestations and Genetic Characterization of Complement Component 6 Deficiency in Brazilian Patients. Blood Adv. 2020;4(11):2456-2464.
Lublin DM, Atik S, Ram S. Meta-analysis of Terminal Complement Complex Deficiencies and Associated Infections. N Engl J Med. 2023;389(12):1105-1118.
Medication Comparisons
Compare medications used to treat Complement Component 6 Deficiency C2676232. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy