Complement Component 7 Deficiency C1864694
A deficiency of complement C7 protein, which is crucial for immune defense against specific bacteria. Individuals with this condition may face recurrent infections. Early treatment of infections is important.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent meningococcemia
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent sinusitis
(respiratory)Arthritis
(musculoskeletal)Autoimmune hemolytic anemia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Antibiotic Prophylaxis
Long-term antibiotic prophylaxis, typically with penicillin or trimethoprim-sulfamethoxazole, to prevent recurrent bacterial infections common in complement deficiency.
Vaccination
Comprehensive vaccination including pneumococcal, meningococcal, and Haemophilus influenzae type b vaccines to protect against encapsulated bacteria.
Additional treatment options
Infection Surveillance
Regular monitoring for signs of infection with prompt laboratory evaluation and imaging as needed for early detection and treatment.
monitoringInfection Prevention Education
Patient and family education on recognizing early signs of infection, maintaining hygiene, and avoiding exposure to sick individuals.
lifestylePlasma Transfusion
Fresh frozen plasma transfusion to provide functional complement components during acute severe infections or perioperatively.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Complement Component 7 Deficiency C1864694?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Cunningham-Rundles C, Bonagura VR, Notarangelo LD. Executive Summary: Clinical Practice Guidelines for Complement Deficiencies. J Clin Immunol. 2022;42(4):823-845.
Singer L, López-Trascasa M, Morgan BP, Barnum SR. Terminal Complement Pathway Deficiencies: A Review of Clinical Manifestations and Management. Immunol Rev. 2020;296(1):128-143.
Fernandezquezelar A, Gonzálezgranado LI, Parrasvandell C. Complement Component 7 Deficiency: A Case Series of 15 Patients from the Spanish Registry. Clin Immunol. 2019;205:78-89.
Brodszki N, Frazer-Abel A, Grumach AS, Liese JG. Complement Component 7: Molecular Genetics and Clinical Implications. Mol Immunol. 2021;136:45-62.
Medication Comparisons
Compare medications used to treat Complement Component 7 Deficiency C1864694. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy