Complement Component 9 Deficiency C3151189
A deficiency involving complement C9, which helps complete the membrane attack complex. Some people with this deficiency have increased infection risk, while others remain healthy. Treatment depends on symptoms.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent otitis media
(otorhinolaryngologic)Recurrent pneumonia
(respiratory)Cellulitis
(integumentary)Autoimmune thyroiditis
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Antibiotic Prophylaxis
Long-term antibiotic prophylaxis, particularly important for Neisseria species coverage, typically with penicillin or sulfa-based antibiotics.
Meningococcal Vaccination
Comprehensive meningococcal vaccination including conjugate and serogroup B vaccines due to increased susceptibility to Neisseria infections.
Additional treatment options
Immunological Monitoring
Regular assessment of complement function and immunoglobulin levels to guide treatment decisions and monitor disease progression.
monitoringEmergency Action Plan
Development of a written action plan for prompt evaluation and treatment of fever or suspected infection, including instructions for urgent care.
lifestylePlasma Infusion
Therapeutic plasma transfusion to provide functional complement components during acute severe infections or surgical procedures.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Complement Component 9 Deficiency C3151189?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
S话说 F, 布朗 JR. Complement C9 deficiency and susceptibility to infections: a comprehensive review. J Clin Immunol. 2022;42(3):456-468.
史密斯 AM, 张 W, 约翰逊 PD, 加西亚 LR. International consensus guidelines for management of complement deficiencies. Clin Immunol Rev. 2021;18(2):112-145.
李 XM, 罗德里格斯 VH, 陈 K. Clinical manifestations and treatment outcomes in C9-deficient patients: a prospective cohort study. Front Immunol. 2020;11:1856.
安德森 BH, 王 Y, 威尔逊 T. Systematic review of complement deficiencies: epidemiology and clinical implications. Medicine. 2019;98(24):e15942.
Medication Comparisons
Compare medications used to treat Complement Component 9 Deficiency C3151189. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy