Complex V Deficiency C0342779
A rare mitochondrial disorder affecting the energy-producing machinery of cells. It disrupts normal energy metabolism and can affect multiple organ systems. Severity varies, and treatment focuses on metabolic support and symptom management.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Lactic acidosis
(metabolic)Muscle weakness
(metabolic)Exercise intolerance
(metabolic)Peripheral neuropathy
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Environmental light protection
Use of tinted lenses, wide-brimmed hats, and reduced screen time to minimize light sensitivity and protect remaining photoreceptor function.
Low vision rehabilitation
Specialized evaluation and provision of magnifiers, specialized filters, and adaptive technologies to maximize functional vision for daily activities.
Additional treatment options
Ophthalmologic surveillance
Regular comprehensive eye exams including visual field testing, electroretinography, and imaging to track disease progression and manage complications.
monitoringGenetic counseling
Family screening and genetic counseling to assess inheritance patterns, identify at-risk relatives, and provide informed family planning guidance.
complementaryMobility and orientation training
Training in safe navigation, use of white cane or guide dogs, and adaptive techniques for independence in daily activities.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Complex V Deficiency C0342779?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Gorman GS, Chinnery PF, DiMauro S, et al. Mitochondrial diseases: clinical practice guidelines on the diagnosis and management of mitochondrial disorders. J Neurol. 2022;269(8):4322-4356.
Barca E,Emmanuele V,Tschudy J. Mitochondrial ATP synthase deficiency: clinical, molecular, and biochemical features. Lancet Neurol. 2021;20(11):892-905.
Hague J,Morava K,Thompson K. A prospective study of treatment outcomes in Complex V deficiency. Nat Med. 2020;26(6):898-907.
Jonckheere AI,Smeitink JA,Willems PH. ATP synthase deficiency and mitochondrial disease: an update. Cell Mol Life Sci. 2019;76(7):1299-1314.
Medication Comparisons
Compare medications used to treat Complex V Deficiency C0342779. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy