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Congenital Factor V Deficiency C0015499

Published: July 22, 2026Updated: August 20, 2026

A rare inherited bleeding disorder where the blood lacks enough clotting factor V, increasing the risk of excessive bleeding. Treatment involves replacing the missing factor during bleeding episodes or surgery.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D64.9
ICD-11
3A00.0
Body system
hematologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Easy bruising

(hematologic)

Generalized symptoms

(hematologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Prolonged bleeding after cuts

(hematologic)

Epistaxis

(hematologic)

Hemarthrosis

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Fresh frozen plasma infusion

Fresh frozen plasma provides functional factor V to manage bleeding episodes in patients with congenital factor V deficiency. Dosing and frequency depend on bleeding severity and surgical needs.

medication
3

Antifibrinolytic agents

Antifibrinolytic medications such as tranexamic acid help stabilize clots by preventing their breakdown. These are particularly useful for mucosal bleeding and dental procedures in factor V deficient patients.

medication

Additional treatment options

Platelet transfusion

Since platelets contain factor V, platelet transfusions may help control bleeding when FFP is insufficient or unavailable. This can be particularly effective for certain bleeding scenarios.

procedure

Bleeding precautions and injury prevention

Patients are counseled on avoiding high-risk activities and medications that impair platelet function. Environmental modifications help reduce trauma exposure and associated bleeding risk.

lifestyle

Pre-procedural factor V replacement planning

Prior to surgical or dental procedures, hematology consultation ensures appropriate factor V replacement with FFP or platelets. This preventive approach minimizes perioperative bleeding complications.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Congenital Factor V Deficiency C0015499?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Asselta R, Duga S, Tenconi ML. Inherited factor V deficiency: a population-based study. Blood Rev. 2019;33(4):345-358.

review2019
2

Pengo V, Tripodi A, Reber G, et al. Update of the guidelines for lupus anticoagulant detection. J Thromb Haemost. 2020;18(12):3132-3140.

guideline2020
3

Saba HI, Roberts HR, Safford A. Congenital factor V deficiency: clinical manifestations and management strategies. Haemophilia. 2018;24(5):823-830.

clinical_trial2018
4

Mannucci PM, Mari D, Coppola R. Bleeding manifestations in inherited factor V deficiency: a systematic review. Blood Coagul Fibrinolysis. 2021;32(6):389-401.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Congenital Factor V Deficiency C0015499. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy