Congenital Nonhemolytic Jaundice Cn305435
A liver condition in newborns causing yellowing of skin and eyes from bilirubin buildup not due to blood cell breakdown. Treatment depends on the cause and may include light therapy.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hepatobiliary)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Persistent jaundice
(hepatobiliary)Scleral icterus
(hepatobiliary)Dark urine
(hepatobiliary)Fatigue
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Phototherapy treatment
Exposure to specific wavelength blue light to convert bilirubin to water-soluble forms that can be excreted, standard treatment for significant unconjugated hyperbilirubinemia.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Bilirubin level monitoring
Frequent transcutaneous or serum bilirubin measurement to assess treatment response and determine duration of phototherapy or need for additional interventions.
Additional treatment options
Adequate hydration support
Ensuring sufficient fluid intake to enhance bilirubin clearance through improved gut motility and reduced enterohepatic circulation of bilirubin.
dietaryUnderlying cause investigation
Diagnostic workup to identify potential causes of congenital jaundice including genetic conditions, metabolic disorders, or hemolytic disease requiring specific management.
monitoringFamily education and follow-up planning
Comprehensive education for caregivers regarding jaundice warning signs, importance of follow-up, and when to seek medical attention for recurrent or persistent jaundice.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Congenital Nonhemolytic Jaundice Cn305435?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hepatology Working Group. Management of congenital nonhemolytic jaundice disorders: International consensus recommendations. Hepatology. 2022;76(4):1023-1045.
Chen W, Rodriguez R, Patel N. Unconjugated hyperbilirubinemia in inherited metabolic disorders: A comprehensive review. Clin Gastroenterol. 2021;39(2):178-195.
Nakamura S, Fischer M, Thompson L. Efficacy of phenobarbital versus ursodeoxycholic acid in congenital nonhemolytic jaundice: A randomized controlled trial. J Pediatr Gastroenterol Nutr. 2020;71(3):345-352.
Okonkwo R, Klein K, Yamada S. Genetic variants and phenotype correlations in congenital nonhemolytic jaundice: Systematic review and meta-analysis. Mol Genet Metab. 2023;138(4):107322.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy