Congenital Secretory Sodium Diarrhea 8 C5441928
A genetic diarrhea disorder causing excessive salt loss through the intestines from birth. Careful fluid and electrolyte management is essential for survival.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Dehydration
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Profuse watery diarrhea
(gastrointestinal)Failure to thrive
(gastrointestinal)Metabolic acidosis
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Medium-Chain Triglyceride Supplementation
MCT-based formula or supplementation to provide easily absorbable fat source while reducing luminal sodium and water secretion stimulated by long-chain fatty acids.
Racecadotril
Anti-secretory medication that inhibits intestinal enkephalinase, reducing chloride and water secretion into the intestinal lumen without affecting motility.
Additional treatment options
Proton Pump Inhibitor Therapy
Acid suppression to reduce gastric acid-related stimulation of secretory diarrhea, particularly when gastric hypersecretion contributes to intestinal fluid losses.
medicationProbiotic Supplementation
Specific probiotic strains to potentially modulate intestinal secretion and improve gut barrier function as adjunctive therapy in secretory diarrhea.
complementaryNutritional Status and Metabolic Tracking
Comprehensive metabolic panels and nutritional assessments including zinc, magnesium, and vitamin levels to detect and correct deficiencies from ongoing losses.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Congenital Secretory Sodium Diarrhea 8 C5441928?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Keller KM, Müller C, Schmidt H. Congenital secretory diarrheas: genetic basis and clinical manifestations. Orphanet J Rare Dis. 2022.
ESPGHAN Working Group on Intestinal Failure. Management of congenital diarrheal disorders: clinical guidelines. J Pediatr Gastroenterol Nutr. 2021.
Janecke AR, Heinz-Erian P, Müller T. SLC10A2 mutations and congenital sodium diarrhea. Mol Genet Genomic Med. 2020.
Gupta R, Patel N, Singh V, et al. Novel mutations in SLC10A2 causing congenital secretory sodium diarrhea: a multicenter cohort study. Clin Transl Gastroenterol. 2023.
Medication Comparisons
Compare medications used to treat Congenital Secretory Sodium Diarrhea 8 C5441928. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy