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Cowden Syndrome 2 Cn293886

Published: July 22, 2026Updated: August 25, 2026

Cowden syndrome 2 is a related genetic condition causing benign tumors and elevated cancer risk. It requires regular medical surveillance and screening. Genetic counseling is often recommended for families.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
C96.9
ICD-11
2A00.0
Body system
oncologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Breast lump

(reproductive)

Generalized symptoms

(oncologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Cutaneous papillomas

(integumentary)

Colon polyps

(gastrointestinal)

Thyroid goiter

(endocrine)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Enhanced Tumor Surveillance Protocol

Regular imaging and laboratory screening for thyroid, breast, endometrial, renal, and colonic neoplasms using evidence-based interval schedules.

monitoring
3

Polypectomy and Lesion Removal

Endoscopic or surgical removal of benign hamartomatous polyps and mucocutaneous lesions that may cause symptoms or undergo malignant transformation.

surgical

Additional treatment options

Cancer-Prevention Nutrition

Anti-inflammatory diet rich in fruits, vegetables, and fiber with reduced processed foods to potentially decrease tumor development risk.

dietary

Integrative Symptom Management

Complementary approaches including acupuncture or herbal support under specialist supervision for managing treatment-related symptoms.

complementary

Family-Based Counseling

Psychological interventions involving the whole family to address anxiety, support treatment adherence, and facilitate communication about genetic risks.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Cowden Syndrome 2 Cn293886?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E. Cowden Syndrome and the PTEN Hamartoma Tumor Syndrome: Systematic Review and Revised Diagnostic Criteria. J Natl Compr Canc Netw. 2013;11(11):1323-1332.

guideline2013
2

Tan MH, Mester JL, Ngeow J, Rybicki LA, Orloff MS, Eng C. Lifetime Cancer Risk in Individuals with Germline PTEN Mutations. Clin Cancer Res. 2012;18(2):421-428.

review2012
3

Henderson CJ, Ngeow J, Collins JA, et al. Increased Cancer Incidence in the PTEN Hamartoma Tumor Syndrome. J Clin Endocrinol Metab. 2020;105(4):1027-1034.

other2020
4

Bubien V, Bonnet F, Brouste V, et al. High Cumulative Risks of Cancer in Individuals with PTEN Mutations. J Med Genet. 2013;50(4):255-263.

meta_analysis2013

Medication Comparisons

Compare medications used to treat Cowden Syndrome 2 Cn293886. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy